Dog Vaccine & Vaccination Guide | Timing, Types, and Costs
Explains the types and vaccination schedules for canine core and non-core vaccines. Covers vaccination timing from puppies to adult dogs, managing adverse reactions, cost estimates, and mandatory rabies vaccination requirements.

Key Takeaways
Explains the types and vaccination schedules for canine core and non-core vaccines. Covers vaccination timing from puppies to adult dogs, managing adverse reactions, cost estimates, and mandatory rabies vaccination requirements.
When bringing home a new dog, one of the first things you should do is get them vaccinated. To protect your dog from infectious diseases, it's important to understand vaccine types, vaccination schedules, costs, and precautions.
Vaccine Types
Canine vaccines are broadly divided into two types: core vaccines and non-core vaccines.
Core Vaccines (Recommended for All Dogs)
These are vaccines recommended for all dogs to prevent highly fatal infectious diseases.
- Canine Distemper Virus (CDV): Progresses from high fever, ocular discharge, cough, and diarrhea to neurological symptoms. Extremely high mortality rate.
- Canine Parvovirus (CPV): Causes severe vomiting, bloody stool, and dehydration. Particularly high mortality rate in puppies.
- Canine Adenovirus Type 1 (CAV-1): Causes canine infectious hepatitis. Acute cases can be fatal within days.
- Canine Adenovirus Type 2 (CAV-2): One of the causes of kennel cough. Type 2 vaccine provides protection against both types 1 and 2.
Non-Core Vaccines (Recommended Based on Lifestyle and Environment)
Vaccines whose administration depends on the dog's living environment and lifestyle.
- Canine Parainfluenza Virus (CPiV): A causative agent of kennel cough. Recommended if your dog frequents dog parks or pet hotels.
- Leptospirosis: Transmitted through water contaminated by wild animal urine. Since it can also infect humans (zoonotic disease), vaccination is recommended for dogs that frequent mountains or rivers.
- Canine Coronavirus: Causes mild diarrhea. Risk of severe illness when co-infected with parvovirus.
- Bordetella (Intranasal Kennel Cough Vaccine): Recommended for dogs that frequently visit pet hotels or dog shows.
Types of Combination Vaccines
The following are the combination vaccines commonly used in Japan.
- 5-in-1: Distemper, Parvovirus, Adenovirus Type 1 & 2, Parainfluenza
- 6-in-1: 5-in-1 + Coronavirus
- 8-in-1: 6-in-1 + 2 Leptospirosis strains
- 10-in-1: 8-in-1 + 2 additional Leptospirosis strains
Vaccination Schedule
Puppy Vaccination Schedule
Puppies require multiple vaccinations because maternal antibodies (immunity passed through nursing) gradually decline.
- First dose (6-8 weeks old): Often already administered by the breeder.
- Second dose (10-12 weeks old): Administered at a veterinary clinic after bringing puppy home.
- Third dose (14-16 weeks old): Final booster to ensure complete immunity.
Important: Until the third dose is complete, avoid exposing your puppy to other dogs (parks, dog parks, etc.).
Adult Dog Vaccination Schedule
- After completing puppy vaccinations, booster shot one year later
- Subsequently, annual booster shots are standard
- Recent trends show more veterinarians extending vaccination intervals based on antibody titer testing (blood tests)
Rabies Vaccination
In Japan, under the Rabies Prevention Law, dogs over 91 days old are required to receive a rabies vaccination once per year.
- Target: All dogs over 91 days old
- Timing: Annual mass vaccination clinics (April-June), or year-round at veterinary clinics
- Cost: Approximately ¥2,550 injection fee + ¥550 vaccination certificate issuance fee = approximately ¥3,100
- Penalty: Non-vaccinated dogs are subject to fines up to ¥200,000
A separate registration fee of ¥3,000 applies for new registrations.
Estimated Vaccination Costs
- 5-in-1 to 6-in-1 vaccines: ¥5,000-8,000 per dose
- 8-in-1 to 10-in-1 vaccines: ¥7,000-10,000 per dose
- Rabies vaccine: Approximately ¥3,100 per dose (including fees)
- Antibody titer testing: Approximately ¥5,000-10,000
Total puppy vaccinations (3 doses): approximately ¥15,000-30,000; annual costs for adult dogs: approximately ¥8,000-13,000.
Adverse Reactions and Precautions
The following adverse reactions may occur after vaccination.
Mild Reactions (Resolve Within Days)
- Swelling or pain at injection site
- Mild fever or reduced appetite
- Temporary decrease in activity level
Severe Reactions (Require Immediate Veterinary Care)
- Facial swelling (moon face)
- Vomiting or diarrhea
- Difficulty breathing or lethargy
- Anaphylactic shock (typically occurs within 30 minutes of vaccination)
Remain at or near the veterinary clinic for 30 minutes to 1 hour after vaccination to confirm no adverse reactions before going home. Small breeds and dogs with a history of allergies have relatively higher risk of adverse reactions and require special attention.
Frequently Asked Questions About Vaccines
Is Annual Vaccination Really Necessary?
Recent trends show more use of antibody titer testing to check for immunity before administering boosters only when necessary. The WASAVA guidelines recommend a 3-year interval for core vaccine boosters. Consult with your veterinarian to determine the optimal schedule for your dog.
Vaccine Types and Target Diseases (Summary)
| Disease | Main Symptoms | Mortality Rate |
|---|---|---|
| Canine Distemper | Fever, nasal discharge, cough, neurological symptoms | Over 50% |
| Canine Parvovirus | Severe vomiting, bloody stool, dehydration | Over 90% if untreated |
| Canine Adenovirus (Hepatitis) | Fever, vomiting, jaundice | Moderate |
For non-core vaccines, the main ones are Leptospirosis (recommended if exposed to contaminated water sources; zoonotic disease), Canine Parainfluenza (kennel cough prevention), and Bordetella (for dogs using pet hotels or dog parks).
Welcome a Healthy Dog with BreederDirect
Trustworthy breeders complete the first vaccination before delivery and provide vaccination certificates. BreederDirect's dog category features many breeders who clearly document vaccination history. After bringing your puppy home, you can consult directly with the breeder about scheduling the 2nd and 3rd vaccinations.